Direct proof of use
Kh-555 use in the 2011 Syrian Civil War is documented in accounts of Russia's November 2015 long-range aviation strikes. CNA's study of the Russian air campaign states that on November 17, 2015, three Tu-95MS-8 bombers fired several Kh-555 missiles after taking off from Russia and flying more than 6,500 kilometers.
War on the Rocks described the same strike expansion as Russia's use of mainland-based long-range aviation in Syria and identified what appeared to be Kh-555 air-to-ground missiles, the conventional Kh-55 variant. Russian Strategic Nuclear Forces also summarized the Russian military account of the operation as involving Tu-95MS and Tu-160 strategic bombers and 34 long-range cruise missiles.
Sources: CNA Russian Air Campaign, War on the Rocks Syria Strikes, Russian Strategic Nuclear Forces Syria Strikes
Timeline
The cited public record centers on the November 17-20, 2015 strike period after Russia announced that the Metrojet Flight 9268 crash had been caused by an Islamic State bomb. CNA describes this as the start of an unofficial four-day retaliation campaign in which Russia added strategic aviation from Russian territory to its Syria air campaign.
On November 17, CNA reports that Tu-160 bombers fired Kh-101 missiles and Tu-95MS-8 bombers fired several Kh-555 missiles. The same study says Russia used 85 air-launched cruise missiles, 18 sea-launched missiles, and 1,400 tons of air bombs over the four-day campaign.
Sources: CNA Russian Air Campaign
Narrative
In Syria, the Kh-555 appears in the public record as a Russian standoff-strike weapon used by long-range aviation on the Syrian government and allied side of the war. The documented launch platform in the cited direct-use source is the Tu-95MS-8 strategic bomber; broader accounts of the operation also include Tu-160 and Tu-22M3 bombers in the same Russian long-range aviation strike package.
The Kh-555 was relevant to this strike series because it was the conventional derivative of the Kh-55 family. CSIS describes the Kh-555 as replacing the Kh-55 nuclear warhead with conventional high-explosive, penetrating, or submunitions payload options and lists Tu-95MS and Tu-160 variants among carrier aircraft for the Kh-55/Kh-555 family.
The sources support Russian use of Kh-555 missiles in Syria in November 2015. They do not support use by opposition, Islamic State, coalition, Turkish, or Israeli forces in the Syrian Civil War.
Sources: CNA Russian Air Campaign, War on the Rocks Syria Strikes, CSIS Kh-55