Direct proof of use
The F-35A Lightning II is directly documented in the 2014 War Against the Islamic State through U.S. Air Forces Central Command reporting on Operation Inherent Resolve. On April 30, 2019, two U.S. Air Force F-35As conducted an airstrike at Wadi Ashai, Iraq, in support of Combined Joint Task Force - Operation Inherent Resolve.
AFCENT described the mission as the F-35A's first combat employment. The aircraft used a Joint Direct Attack Munition against an entrenched Daesh tunnel network and weapons cache in the Hamrin Mountains, a target area the release said could threaten friendly forces.
Sources: AFCENT F-35A First Combat Employment
Timeline
The F-35A deployment reached the U.S. Central Command area of operations on April 15, 2019, when aircraft from Hill Air Force Base joined the Combined Forces Air Component team. The first documented strike followed on April 30 at Wadi Ashai, Iraq.
AFCENT's April 2019 airpower summary later repeated the Wadi Ashai strike and placed it within the Iraq-Syria air campaign for that month, when U.S. and coalition pilots flew strike and intelligence, surveillance, and reconnaissance sorties in support of coalition and partner ground forces' ISIS clearance operations.
Sources: AFCENT F-35A First Combat Employment, AFCENT April 2019 Airpower Summary
Operational role
The documented F-35A role in this conflict was precision air interdiction and strike against an ISIS tunnel-and-cache target. The public official releases identify the aircraft, operator context, operation, location, target category, and munition family, but they do not provide aircraft tail numbers, exact aimpoints, or a longer sortie history for the type in Operation Inherent Resolve.
The F-35A record therefore rests on a specific confirmed combat mission rather than a broad claim about continuous use. In the catalog's conflict-role model, the Wadi Ashai strike supports long-range strike and interdiction because the aircraft attacked a weapons cache and tunnel network in support of coalition and partner operations against ISIS.
Sources: AFCENT F-35A First Combat Employment, AFCENT April 2019 Airpower Summary