Direct proof of use
The clearest direct-use record comes from July 2021. TASS, citing Vadim Kulit of the Russian Center for Reconciliation of the Opposing Parties in Syria, reported that Syrian army Buk-M2E systems destroyed four guided missiles fired by Israeli F-16s at facilities in Homs province from Lebanese airspace on July 22. The same report said Pantsir-S and Buk-M2 systems had intercepted seven of eight Israeli guided missiles fired southeast of Aleppo earlier that week.
European Security & Defence reported another Russian-media account in August 2021 in which Syrian air-defense forces intercepted Israeli missiles launched from Lebanese airspace; it identified the Russian-origin systems involved as Buk-M2E and Pantsir-E, and separately cited SIPRI delivery data for 18 Syrian 9K317E Buk-M2E units in 2011.
Sources: TASS Homs Buk-M2E Interception, European Security & Defence Russian Air Defence Systems Used in Syria
Timeline
Buk-M2E was present in Syrian government air-defense service by the war period: European Security & Defence cited SIPRI data that 18 9K317E Buk-M2E units were delivered to Syria in 2011. On April 14, 2018, U.S., UK, and French forces struck Syrian government chemical-weapons-related sites; a Russian Defence Ministry briefing republished by Deagel said Syrian air-defense forces fired 29 Buk-system missiles during the response, while U.S. officials said Syrian surface-to-air missiles were largely ineffective and did not successfully engage coalition aircraft or missiles.
In July and August 2021, Russian and defense-media reporting placed Buk-M2E/Buk-M2 systems in Syrian government air-defense engagements against Israeli guided missiles over Homs province, southeast of Aleppo, and in a later August strike context.
Sources: European Security & Defence Russian Air Defence Systems Used in Syria, Deagel Russian Defence Ministry Syria Strike Briefing, DoD Syria Strike Briefing, DoD Syria Strike Story, TASS Homs Buk-M2E Interception
Narrative
In Syrian government service, the Buk-M2E functioned as a medium-range air-defense layer rather than a ground-attack weapon. Rosoboronexport describes the export Buk-M2E as a medium-range air-defense missile system for protecting troops, military installations, administrative and industrial facilities, and territory against aircraft, helicopters, cruise missiles, other aerodynamic targets, tactical ballistic and aviation missiles, and guided bombs.
The documented Syrian Civil War use centers on defending government-controlled territory and facilities from foreign air and missile strikes. The July 2021 Homs account specifically attributed the intercepts to Syrian army Buk-M2E systems. The April 2018 coalition strike record is more contested: Russian reporting credited Syrian Buk-system fire with interceptions, while U.S. briefings said Syrian launches mostly occurred after the strike's final impacts and did not successfully engage coalition missiles or aircraft.
Sources: Rosoboronexport Buk-M2E, TASS Homs Buk-M2E Interception, Deagel Russian Defence Ministry Syria Strike Briefing, DoD Syria Strike Briefing, DoD Syria Strike Story