Direct proof of use
The MIM-104 Patriot is directly documented in the 2011 Syrian Civil War through Israeli firing and interception events connected to Syrian aircraft and drones near the Golan Heights. The Israel Defense Forces said that on July 24, 2018 it launched two Patriot missiles and shot down a Syrian Air Force Sukhoi Su-22/24 after the jet entered Israeli airspace from Syria.
Earlier Israeli use is documented in IDF and CSIS material. The IDF stated that a Patriot system intercepted and neutralized a drone that infiltrated Israel from Syria on August 31, 2014, and that a Syrian combat plane was intercepted by a Patriot missile on September 23, 2014. CSIS Missile Threat summarizes Israeli Patriot use in 2014 against two Syrian drones and a Syrian Su-24, a 2016 engagement that missed a drone from Syria, a November 2017 Syrian drone intercept near the Golan Heights, and 2018 shootdowns of a Syrian drone and a Syrian Su-24.
Sources: IDF Syrian Fighter Jet, IDF Patriot Aerial Defense, CSIS Patriot
Timeline
Patriot's Syrian-war role began as both a border-protection deployment and an Israeli air-defense capability. NATO allies deployed Patriot batteries in Turkey from January 2013 after Turkey requested assistance because of instability on the Syrian border and the potential missile threat from Syria. Spain later took over the Adana mission from the Netherlands with Patriot launchers and radar, while U.S. and German Patriot units were positioned at Kahramanmaras and Gaziantep.
The Israeli engagement record then developed around spillover from the Syrian front. Publicly documented events include the August and September 2014 intercepts of a Syrian drone and combat aircraft, a June 2018 Patriot launch at a UAV near the Golan Heights, July 2018 Syrian UAV engagements, and the July 24, 2018 shootdown of a Syrian Sukhoi-model fighter.
Sources: Spanish Army Patriot Deployment, Incirlik Active Fence Handover, IDF Patriot Aerial Defense, CSIS Israel Launches Patriot at UAV, CSIS Second UAV Intercept, IDF Syrian Fighter Jet
Narrative
In Israeli service, Patriot functioned as a high-readiness air-defense layer for the northern front rather than as a ground-attack weapon. The cited events place the system in a border-defense role against aircraft or UAVs associated with fighting in Syria, especially around the Golan Heights, the demilitarized zone, and Israeli airspace. The evidence supports launches, successful intercepts, and at least one missed engagement; it does not establish a complete public log of every Patriot firing during the war.
In Turkey, Patriot was fielded by NATO allies for deterrent and defensive coverage rather than recorded combat intercepts. Spanish Army material says the Syrian civil war and instability on the Turkish border led Turkey to request NATO assistance, and that the operation was launched to help protect Turkish airspace in January 2013. U.S. Air Force coverage of the Dutch-to-Spanish handover described the mission as a NATO Patriot support deployment that protected Turkey after an air-defense assistance request.
Sources: CSIS Patriot, IDF Syrian Fighter Jet, Spanish Army Patriot Deployment, Incirlik Active Fence Handover