Direct proof of use
The 155 mm artillery round is directly documented in the anti-ISIS campaign through U.S. Army reports from Iraq in late 2018. At Firebase Saham, a U.S. M777A2 crew fired volleys of 155 mm high-explosive shells while supporting efforts to stop ISIS fighters moving near the Iraq-Syria border.
A separate U.S. Army report on Operation Swift described a 155 mm artillery round leaving an M777A2 during a coalition gun raid in Iraq's Makhmour Mountains on December 22, 2018. The raid paired artillery and airstrikes against ISIS targets and was conducted in coordination with Iraqi Security Forces.
Sources: Troopers Conduct Powerful Gun Raid Against ISIS, Firebase Saham: A Day in the Life of Joint-Artillerymen Securing the Iraq Border
Firebase Saham
Firebase Saham was established near Iraq's border with Syria in November 2018. U.S., French, and Iraqi artillery units operated there to support the Middle Euphrates River Valley offensive and to prevent ISIS fighters from crossing into Iraq.
The artillery mix at the firebase included U.S. M777 howitzers, French CAESAR 155 mm self-propelled howitzers, and Iraqi M109 Paladins. The U.S. Army article specifically identifies M777A2 crews firing 155 mm high-explosive shells, while DVIDS imagery from November 20, 2018 shows 3rd Cavalry Regiment field-artillery soldiers firing an M777A2 in support of Iraqi Security Forces.
Sources: Firebase Saham: A Day in the Life of Joint-Artillerymen Securing the Iraq Border, Firebase Saham Artillery Mission