Direct proof of use
The AGM-158 JASSM family is documented in the 2025 Israel-Iran Conflict through U.S. use during Operation Epic Fury, the 2026 U.S. air campaign against Iran that followed the June 2025 Israel-Iran war phase. CSIS reported that Bloomberg had put first-month Operation Epic Fury JASSM use at more than 1,000 missiles and that the New York Times later put JASSM-ER expenditure at about 1,100.
Air & Space Forces Magazine separately reported that U.S. aircraft had used the Joint Air-to-Surface Standoff Missile in the conflict and described B-52s at RAF Fairford carrying JASSMs during Operation Epic Fury. CENTCOM's public operation page and fact sheet establish the official U.S. operation, Iran target set, and bomber force context, but the munition-specific JASSM use claim rests on CSIS and Air & Space Forces reporting.
Sources: CSIS Last Rounds Iran War Ceasefire, Air & Space Forces B-52 JDAMs Iran, CENTCOM Operation Epic Fury Page, CENTCOM Operation Epic Fury Fact Sheet
Timeline
Operation Epic Fury began on February 28, 2026, according to CENTCOM's April 6 fact sheet. The same fact sheet listed B-1, B-2, and B-52 bombers among U.S. assets employed and identified target categories including command-and-control centers, IRGC facilities, integrated air-defense systems, ballistic-missile sites, anti-ship missile sites, and military support infrastructure.
By early April 2026, Air & Space Forces was reporting that B-52s had begun the war with standoff munitions and that aircraft in the campaign had used JASSM. CSIS later assessed the munitions picture at the Iran war ceasefire and cited reports of more than 1,000 JASSMs used in the first month and about 1,100 JASSM-ERs used overall.
Sources: CENTCOM Operation Epic Fury Fact Sheet, Air & Space Forces B-52 JDAMs Iran, CSIS Last Rounds Iran War Ceasefire
Operational role
The documented role of JASSM in this conflict was long-range U.S. standoff strike. The missile allowed bomber aircraft to attack Iranian military and security targets while retaining a standoff employment option, especially during the earlier phase of Operation Epic Fury when reporting described B-52s using standoff munitions before later overland JDAM missions.
Public sources do not identify every JASSM target, launch platform, or missile variant for each strike. The source-backed record is therefore limited to U.S. employment of the JASSM family, including JASSM-ER expenditure reported at scale, during Operation Epic Fury against Iran.
Sources: CSIS Last Rounds Iran War Ceasefire, Air & Space Forces B-52 JDAMs Iran
