Direct proof of use
Israel used Arrow 2 during the 2011 Syrian Civil War on March 17, 2017, when Israeli air-defense forces intercepted a Syrian SA-5/S-200 surface-to-air missile after Israeli aircraft carried out strikes in Syria. Defense News reported that a senior Israeli Air Force officer confirmed the Arrow 2 scored its first operational intercept against a Syrian SA-5.
The engagement followed Syrian surface-to-air missile launches at Israeli aircraft returning from a strike mission. Israeli reporting and later missile-defense analysis described the intercepted missile as behaving like a ballistic threat, which brought it within Arrow 2's defensive role even though the target was not the ballistic-missile class for which the system was originally designed.
Sources: Defense News Syrian SAM Intercept, Times of Israel Air Defense Command, CSIS Arrow Syrian SAM
Timeline
Early on March 17, 2017, Israeli aircraft struck targets in Syria and Syrian air defenses fired missiles after the mission. The Guardian quoted an Israeli military statement saying aircraft had targeted several sites in Syria, anti-aircraft missiles were launched from Syria after the mission, and Israeli aerial-defense systems intercepted one missile.
On March 20, 2017, Israeli air-defense officials publicly explained the Arrow launch. Brig. Gen. Tzvika Haimovitch, head of Israel's Aerial Defense Command, said the intercepted missile was headed toward the Jordan Valley and contained a large explosive charge; Defense News reported the same briefing as confirmation that the interceptor was Arrow 2 and the Syrian missile was an SA-5.
Sources: Guardian Syria Mission, Times of Israel Air Defense Command, Defense News Syrian SAM Intercept
Narrative
The Arrow 2 appearance in this conflict was defensive and incident-specific. Israel was not using Arrow 2 as a strike weapon in Syria; it was operating the interceptor inside Israel's layered air-defense network to protect Israeli territory and aircraft after Syrian government air defenses fired during the cross-border exchange.
CSIS Missile Threat assessed that the event marked Arrow 2's operational debut and noted that early reports had created confusion with Arrow 3. Its explanation distinguished the two interceptors: Arrow 3 uses an exo-atmospheric kill vehicle, while Arrow 2 carries a blast-fragmentation warhead capable of destroying the surface-to-air missile involved in this engagement.
A separate CSIS S-200 profile placed the Syrian missile in the wider air-defense context of the war, reporting that Syrian forces fired 5V21 missiles from S-200 systems after an Israeli strike on a weapons convoy linked to Hezbollah. That profile says one 5V21 was intercepted by Israel's Arrow 2 and that Syria's claim of downing an Israeli aircraft was not corroborated.
Sources: CSIS Arrow Syrian SAM, CSIS S-200 Syria Profile, Guardian Syria Mission