Direct proof of use
The documented Afghanistan record for the M722A1 is a transfer and sustainment record rather than a firing report. A Small Arms Survey dataset lists an Afghan National Army sustainment ammunition line for 11,536 cartridges described as 60 mm white phosphorus M722A1, implemented on March 8, 2010.
A later Small Arms Survey briefing on weapons supplied to Afghanistan between 2002 and 2021 also lists M722A1 (WP) 60 mm mortar rounds among light-weapons ammunition exported to Afghanistan. Together, these sources support supply to Afghan government forces during the 2001 War in Afghanistan, while leaving actual battlefield expenditure unconfirmed.
Sources: Small Arms Survey Afghanistan Arms Transfers Dataset, Small Arms Survey Calculable Losses Briefing
Narrative
The cartridge's role in the Afghanistan record is best described as partner-force sustainment ammunition. The Army describes the M722A1 as a spotting and marking smoke round for the M224/M224A1 60 mm mortar family; the Afghanistan-specific record places that cartridge in Afghan National Army ammunition support during the war.
The available public sources do not identify a named engagement, firing unit, target, or post-strike effect involving the M722A1 in Afghanistan. For this conflict, the source-backed claim is therefore transfer and fielding context for Afghan government forces, not independently verified combat firing.
Sources: PEO Ammunition 2017 Portfolio Book, Small Arms Survey Afghanistan Arms Transfers Dataset, Small Arms Survey Calculable Losses Briefing