Direct proof of use
The FAB-500M-54 GPB is documented in the Syrian Civil War through Russian air operations that began on September 30, 2015. A January 2016 Polish Institute of International Affairs bulletin on Russia's first three months of intervention listed FAB-500M-54 high-explosive bombs among the munitions used by Russian forces in combat operations in Syria.
A specific battlefield record appears in the Open Source Munitions Portal. OSMP entry 481 records an air-delivered bomb at Talbisah, Homs, dated September 30, 2015, with the tentative model listed as FAB-500 M54. The same entry classifies the munition as an unguided 500 kg air-to-surface blast and fragmentation munition and links the record to Airwars' Talbisah incident for the first day of Russian bombing.
Sources: PISM Russian Intervention in Syria 2016, OSMP481 FAB-500 M54 Syria, Airwars RS0003 Talbisah
Timeline
On September 30, 2015, Russia began air operations in Syria in support of the Syrian government. The Talbisah record is dated to that same day: OSMP describes a delivered, unfunctioned air-delivered munition at Talbisah and identifies it tentatively as FAB-500 M54, while Airwars records reported Russian aircraft strikes at Talbisah on the first day of the campaign.
By early January 2016, PISM summarized the first three months of Russian operations and named FAB-500M-54 among the bomb types used alongside guided KAB-series bombs, BetAB-500 penetration bombs, S-8 rockets, and long-range cruise missiles.
Sources: OSMP481 FAB-500 M54 Syria, Airwars RS0003 Talbisah, PISM Russian Intervention in Syria 2016
Battlefield role
The documented role was unguided air-delivered blast and fragmentation attack by Russian aircraft on the Syrian government-and-allies side. PISM places FAB-500M-54 use inside a broader Russian air campaign involving tactical aircraft, strategic bombers, cruise missiles, unguided rockets, and several bomb families.
The Talbisah evidence should be read as a tentative item-level identification rather than a complete strike reconstruction. OSMP's record identifies the model as tentative and notes that the M-54 high-drag series is normally distinguished by features including a forward ballistic ring and longitudinal levelling bars; in the Talbisah example, OSMP notes the ballistic ring was missing while two levelling bars were visible.
Sources: PISM Russian Intervention in Syria 2016, OSMP481 FAB-500 M54 Syria, OSMP FAB-500 M54 model