Direct proof of use
Action on Armed Violence profiled the OFAB-100-120 in September 2013 as one of the explosive weapons in use in Syria and described it as an unguided bomb family owned by Syria and deliverable from several Syrian fighter jets. Business Insider's same-day summary of AOAV's investigation identified air-dropped munitions including the OFAB-100-120 as weapons exclusive to forces loyal to Bashar al-Assad and tied the regime air war on rebel-held territory to July 2012.
Deagel separately identifies the FAB-100 as a 100 kg Russian general-purpose bomb and reports its employment during the Russian Air Force campaign in Syria in 2016 and 2017 from Su-24M bombers equipped with the SVP-24 targeting module.
Sources: AOAV OFAB-100-120, Business Insider AOAV Dirty Dozen, Deagel FAB-100
Timeline
Syrian government air operations against rebel-held areas were underway by July 2012, according to the AOAV material summarized by Business Insider. AOAV then published its OFAB-100-120 profile on 23 September 2013 as part of a wider investigation into explosive weapons used in Syria.
The Russian air campaign began later in the war. Deagel reports FAB-100 use in Syria in 2016 and 2017, specifically linking the bomb to Russian Su-24M releases during that campaign.
Sources: AOAV OFAB-100-120, Business Insider AOAV Dirty Dozen, Deagel FAB-100
Narrative
In Syrian service, the OFAB-100-120 evidence places the 100 kg bomb class in the government's fixed-wing air campaign rather than with opposition ground forces. The available public sourcing supports use as an unguided air-dropped bomb, but it does not identify a complete sortie list, individual aircraft serials, or a count of bombs dropped.
Russian use represents a later allied-government phase of the same conflict. Deagel's account connects FAB-100 employment to Russian Su-24M bombers in Syria in 2016 and 2017, distinguishing Russian operational use from earlier Syrian possession and air-delivery reporting.
Sources: AOAV OFAB-100-120, Business Insider AOAV Dirty Dozen, Deagel FAB-100